Ribocentre-aptamer is a publicly accessible aptamer dataset and searchable database containing comprehensive information on all APtamers. RNA aptamers are oligonucleotides with high binding affinity and specificity to target molecules, which are expected to become a new generation of therapeutic molecules and targeted delivery materials.

Ribocentre is designed to contain comprehensive information of all natural ribozymes. Ribozymes are good systems for understanding the ‘sequence - structure - function’ relationship of RNA molecules, since ribozymes are found in the genomes of species from all kingdoms of life and play a role in important reactions such as peptide-bond formation, RNA splicing, transfer RNA biosynthesis, and viral replication. This is therefore an excellent time to summarise these properties, and our new web-based database will make this generally accessible (Accessing the Ribocentre).

Riboswitch is a regulatory segment of a messenger RNA molecule that binds a small molecule, resulting in a change in production of the proteins encoded by the mRNA. Thus, an mRNA that contains a riboswitch is directly involved in regulating its own activity, in response to the concentrations of its effector molecule. The discovery that modern organisms use RNA to bind small molecules, and discriminate against closely related analogs, expanded the known natural capabilities of RNA beyond its ability to code for proteins, catalyze reactions, or to bind other RNA or protein macromolecules (Accessing the Riboswitch).


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Zhichao Miao, Lin Huang
Ribocentre-aptamer: a database of aptamers.
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